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Bifenthrin and imidacloprid come together to target bed bugs in the form of Bithor Dual Action Insecticide. 

Bithor Dual Action with its unique dual mode of action has proven to be an optimal solution for the control of bed bugs, including pyrethroid resistant strains. Ensystex’s regional director, Steve Broadbent, explained, “This is due to the fact that we have blended together two residual insecticides, each with a totally different mode of action, from two different chemical groups (3A and 4A) to create an unstoppable killing weapon for professional pest managers.”

In trials performed at the Institute of Clinical Pathology and Medical Research at Westmead Hospital, against a highly pyrethroid-resistant strain of the common bed bug (Cimex lectularius Linnaeus), Bithor provided 100% control after two hours exposure. Similarly, in trials against a pyrethroid- resistant strain of the tropical bed bug (Cimex hemipterus Fabricus), performed by the Department of Medical Entomology in Thailand, Bithor proved 100% effective in all replicates, and outperformed all other products tested.

“It’s becoming apparent that bed bugs have a formidable arsenal of mechanisms to deactivate insecticides, including target site (nerve) insensitivity, metabolic detoxification and reduced penetration of the insect cuticle. What makes this concerning is that there are few residually effective insecticides today with differing modes of action against bed bugs. This is where Bithor Dual Action comes to the rescue.

“Bithor Dual Action provides fast initial control of bed bugs together with improved residual performance and, most importantly, Bithor has been shown to control all life stages of the bed bug. The enhanced potency of Bithor Dual Action arises from the potentiation that occurs between the two active ingredients. This means that each active makes the other more effective. And since they work at different target sites on the insect nervous system, the end result is the most powerful and versatile insecticide on the market.”

Bifenthrin attacks the sodium channels along the nerve fibre, so it operates as an axonic toxin; whilst imidacloprid strikes at the acetylcholine receptors at the nerve synapse, so it is a synaptic toxin. This dual action ensures insects that may have developed resistant genes for one of the groups due to previous exposure or even natural selection do not survive when Bithor is used.

“Together, they are the ‘Silent Assassins’, since Bithor is uniquely non-repellent to insects. This means insects are not repelled and, as a consequence, it means they remain in contact with treated surfaces for longer, which leads to Bithor’s improved residual performance. Ensystex have achieved a uniquely non-repellent product due to two factors. The first of these is Blended Active Concentrate (BAC) Technology. The two actives are actually milled together at the very start of the production process, so they meld together, allowing the imidacloprid to conceal the bifenthrin.

“More importantly, the molecular structure of bifenthrin is very different to other residual pyrethroids. Bifenthrin is a non-cyano pyrethroid. All other commonly used residual pyrethroids are cyano pyrethroids. This means they have a carbon atom joined to a nitrogen atom by a triple bond.

“The stinging, burning, or tingling sensations that are often experienced by pest managers handling pyrethroids are most prevalent with exposure to pyrethroids whose structures include this cyano group. The toxicity of pyrethroids in mammals is caused by similar mechanisms as the insecticidal activity, so these properties are usually correlated, and hence the high repellence to insects noted with cyano group pyrethroids like beta-cyfluthrin, deltamethrin, cypermethrin and lambda-cyhalothrin.

“Bithor Dual Action is uniquely able to claim the benefits of non-repellence and improved performance – the Silent Assassins.”